Arcus Biosciences, Inc.

Arcus Biosciences is seeking a highly motivated and team-oriented individual for the position of Research Associate in the Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful candidate will be responsible for conducting in-vitro ADME studies, qualitative and quantitative analysis of small molecules using LC-MS/MS, to support multiple drug discovery and development projects.

Responsibilities include, but are not limited to:

• LC-MS/MS method development and quantitative analysis of in vitro and in vivo samples in various biological matrices.
• Perform in vitro ADME assays such as metabolic stability, CYP inhibition, plasma protein binding and blood to plasma partitioning; develop new assays as needed.
• Conduct in vitro and in vivo metabolite identification and profiling studies using LC-MS/MS and/or LC-radio chromatography.
• Analyze preclinical pharmacokinetic and toxicokinetic samples as needed.
• Perform data analysis and reporting of experimental results to project teams.
• Operation, maintenance and troubleshooting of LCMS instruments.

 Qualifications:

• BS/MS degree in chemistry or related scientific discipline with 1-4 years of relevant experience.
• Solid background in organic chemistry and good knowledge of DMPK principles.
• Hands-on experience in LC-MS/MS method development on SCIEX triple quadrupole mass spectrometer is required.
• Experience with in vitro ADME assays highly desirable.
• Experience with Thermo Orbitrap and liquid handling systems would be a plus.
• Strong work ethic, self-motivated, and proven ability to work both independently and collaboratively in a team environment.
• Excellent communication and writing skills.